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      • BIOREGEN
      • Regenflex / Regenflex Starter / Regenflex BIO-PLUS
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bio-revlumetry the 4th dimension in aesthetic medicine

BIORIVOLUMETRIA makes it is possible to COMBAT AGEING through AUGMENTATION of VOLUME and DERMAL AND HYPODERMAL STIMULATION.

When a face gets older the adipose compartments move and becomes thinner, which, in some cases, causes asymmetries of the face. The lack of a structural support, on its turn, causes a relaxation of soft tissues, that makes the aged face look hypo-trophic and loose.

RESTORATION OF VOLUMES AND BOOSTING OF A TISSUE RESTRUCTURING PROCESS

  • Biorivolumetria

  • Manufacturing Technology

  • Studies

  • Hypo-Volumes

A cross-linked and an intercalated slow-release types of HA – are closely combined in the Biorivolumetria products:

  • CROSS-LINKED HA performs a structural volumizing function
  • INTERCALATED SLOW-RELEASE performs a bio-interactive action of receptor stimulation

SCAFFOLD Action Cross-linked HA  Biodegradable scaffold Plays the role of a structural platform that is partially inert and more resistant thanks to its being cross-linked   RE-STRUCTURING Action Free or slow-release HA  Bio-interactive gradually released with the effect of stimulating the HYPO-DERMA Interaction on CD44 receptors of the MSC (Mesenchymal Stem Cells)

structure under microscope

micrscopio_biorivolumetria_eng

The Hyaluronic Acid

Interacts with the CD-44 RECEPTORS and favors an Up-regulation action of the receptor itself, which on its turn accelerates the cellular processes (Migration - Adhesion – Cellular  Differentiation).

Spreading within the tissues

The product spreads immediately within the tissues, which provides for a better tissue integration

titolo_tecnologia_produttiva_eng

The Biorivolumetria products are mono-phase gels manufactured with a long-lasting cross-linking process at low temperature – “gentle cross-linking” (FIG.1). The slow mixing allows for the cross-linking agent (BDDE) to widespread better and in a more uniform manner. The amount of BDDE used is 30 per cent lower than in the majority of other products with the same degree of viscosity available on the market. Moreover, in the case of BIO-EXPANDER three molecular weights of hyaluronic acid are implemented: at 1million, 2 million and 500 thousand Dalton; the latter corresponds to 10 per cent of native and intercalated HA (FIG.2). Differently long HA chains allow for a better calibration of the product’s viscosity.

struttura_acido_ialuronico_eng

studi_biorivolumetria_eng

The face, in its morphological variations, has peculiar properties linked to the distribution of volumes across various areas, such as the bone and muscular structure and compartmental fat. The age-related physiognomic alterations are compromised by:

  • A progressive reduction of fluid in the junction and extra-cellular spaces
  • A structural alteration of the dermal and epidermal configuration

When choosing a biorivolumetria product for a patient, the FACIAL HYPO-VOLUMES.

These can be divided into:

  • LOCAL HYPO-VOLUMES
  • HYPO-VOLUMETRIC DE-STRUCTURINGS

LOCAL HYPO-VOLUMES (LH)

  • FILLING
  • RECEPTOR STIMULATION
  • ELASTICITY
  • YOUNGER PATIENS
  • THE CONSTITUTIONAL ASPECT PREVAILS
  • SOFT AND BONE TISSUES ARE NOT OR ARE POORLY INVOLVED

destrutturazioni_eng1
The hypo-volumetric aspect prevails over the de-structuring, whereby the latter is in its early or a little developed stage. In addition, a correct hydration and extra-cellular osmolarity are found.

HYPO-VOLUMETRIC DE-STRUCTURING (HD)

  • DIFFUSIVITY
  • HYDRATION
  • SOFTNESS
  • FLEXIBILITY
  • RECEPTOR STIMULATION
  • OLDER PATIENTS
  • MORE WIDESPREAD HYPO-VOLUMES
  • INVOLVEMENT OF DERMAL-HYPODERMAL BONE STRUCTURES

destrutturazioni_eng
The reduction of the hypodermal layer is more widespread and is related to an advanced damage of the dermal structure and to a reduced concentration of fluid inside the extra-cellular compartment.

3 concepts in the name
Bio-Ri-Volumetria

  • BIO – BIOCOMPATIBLE AND BIO-ABSORBABLE SUBSTANCES
  • RI – RE-GENERATION AND RE-STRUCTURING
  • VOLUMETRIA – CREATION OF NEW VOLUMES

How was it possible to reach this target?

By optimizing the material and manufacturing process and making them fully patient and environment friendly Using absolutely pure Hyaluronic Acid of the highest quality and reducing the use of BDDE to the lowest level Thanks to the invention of a special PATENTED CHEMICAL PROCESS proving its proper therapeutic efficacy

HIGHLY PURE HYALURONIC ACID

The HYALURONIC ACID supplied by FIDIA FARMACEUTICI, stands for the maximum quality standard of the manufacturing process in terms of raw material purity; in the specific, the complete absence of nucleic acids and proteins guarantees for:
– SUPERIOR QUALITY
– ABSOLUTE SAFETY

Biorivolumetria products

  • biorivolumetria_kit_thumb
    Details
    ADDED

    Biorivolumetria KIT

    It is important to offer the physician an opportunity to have always within reach various types of products in one single casket. And here it is, the “BIORIVOLUMETRIA KIT”, containing 6 packages of injection products:

    Package Contents

    1 REGENYAL IDEA BIO-EXPANDER 3 X 1.1ml
    1 REGENYAL IDEA 1 X 1ml
    1 REGENYAL IDEA LIPS 1 X 1ml
    1 REGENYAL SUPER IDEA KIT 3 X 1ml
  • bio-expander_new
    Details
    ADDED

    Regenyal Idea Bio-Expander

    Regenyal Idea BIO-EXPANDER is a remarkable Biorivolumetria product, that enables a complete rejuve- nation of the face through volumetric correction and tissue re-structuring. The product integrates perfectly and restores natural shapes in an extraordinary manner.

    Package Contents

    Set of three 1.1 ml doses 3 X 1,1ml
    information leaflet
    sealed blister packs containing: a pre-filled sterile single use syringe
    adhesive labels to stick to the patient’s medical records for product identification
    1 sterile needle and 1 sterile cannula 26 G 13 mm / 27 G 37 mm Needle Concept (CE 0499)
  • kit regenyal super idea
    Details
    ADDED

    Regenyal Super Idea KIT

    Regenyal Super Idea is a re-absorbable biorivolumetria product (sterile, apyrogenic and physiological gel) meant for:

    • VOLUME RESTORATION
    • CORRECTION OF DEEP SKIN SAGGING

    The main component is cross-linked Hyaluronic Acid of non animal origin and obtained through bacterial fermentation.

    Package Contents

    3 packages of Super Idea 1x1ml
    package insert leaflet
    sealed blister containing: 3 pre-filled sterile mono-dose/mono-use syringe
    stickers to apply to the patient’s sheet for product traceability.
    3 sterile needle 23 G 19mm (TSK CE 0123)
    3 sterile cannula 25 G 38mm (TSK CE 0123)
  • super_idea_pack_ok3
    Details
    ADDED

    Regenyal Super Idea

    Regenyal Super Idea is a re-absorbable biorivolumetria product (sterile, apyrogenic and physiological gel) meant for:

    • VOLUME RESTORATION
    • CORRECTION OF DEEP SKIN SAGGING

    The main component is cross-linked Hyaluronic Acid of non animal origin and obtained through bacterial fermentation.

    Package Contents

    1 ml single package 1 X 1ml
    package insert leaflet
    sealed blister containing: 1 pre-filled sterile mono-dose/mono-use syringe
    stickers to apply to the patient’s sheet for product traceability.
    1 sterile needle 23 G 19mm (TSK CE 0123)
    1 sterile cannula 25 G 38mm (TSK CE 0123)
  • idea_pack_new
    Details
    ADDED

    Regenyal Idea

    Regenyal Idea is a re-absorbable biorivolumetria product (sterile, apyrogenic and physiological gel) used as filling material in corrections of medium kind of skin sagging of the face.

    Package Contents

    1ml single dose 1 X 1ml
    information leaflet
    sealed blister pack containing: a pre-filled sterile single use syringe
    adhesive labels to stick to the patient’s medical records for product identification.
    two sterile needles 27G Sterimedix CE 0120
  • lips_pack_new
    Details
    ADDED

    Regenyal Idea Lips

    Regenyal idea lips is a product created exclusively for interventions on lips.

    Package Contents

    1 ml single dose

    1 X 1ml

    information leaflet
    sealed blister pack containing:

    a pre-filled sterile single use syringe

    adhesive labels

    to stick to the patient’s medical records for product identification.

    two sterile needles

    27 G Sterimedix CE 0120 – 30 G Sterimedix CE 0120

DOWNLOAD BROCHURE

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DOWNLOAD LEAFLET

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Featured Products

  • biorivolumetria_kit_thumb Biorivolumetria KIT
  • bioregen BIOREGEN

Press

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Corporate Video – Regenyal Laboratories & Phitogen Holding

Regenyal Laboratories and Phitogen Holding represent a dynamic and constantly growing reality at international level. Phitogen mainly works with third

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Biorivolumetria event, 24-27 October

From October 24th to 27th we had the pleasure of hosting doctors and distributors from the following countries in San

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